Article

Senolytic Intervention Improves Cognition, Metabolism, and Adiposity in Female APP <sup>NL-F/NL-F</sup> Mice

2023-12-13

Abstract excerpt

Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer’s disease (AD). The APP NL-F/NL-F amyloidogenic AD mouse model exhibits increased markers of senescent cells and the senescence-associated secretory phenotype (SASP) in visceral white adipose tissue before plaque accumulation and cognitive decline. We hypothesized that senolytic intervention would alleviate cell...

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Literature Corpus work: 3a8ec530-6b96-560d-8d02-4c0aaa03dd30
DOI: 10.1101/2023.12.12.571277

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