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Article

Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Manso Yasmina, Comes Gemma, López-Ramos Juan C, Belfiore Mónica, Molinero Amalia, Giralt Mercedes, Carrasco Javier, Adlard Paul A, Bush Ashley I, Delgado-García José María, Hidalgo Juan

Abstract excerpt

Alzheimer's disease (AD) is the most commonly diagnosed dementia, where signs of neuroinflammation and oxidative stress are prominent. In this study we intend to further characterize the roles of the antioxidant, anti-inflammatory, and heavy metal binding protein, metallothionein-1 (MT-1), by crossing Mt1 overexpressing mice with a well-known mouse model of AD, Tg2576 mice, which express the human amyloid-β...

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Identifiers

PMID: 26836194
DOI: 10.3233/JAD-151025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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