Parkinson’s disease-associated shifts between DNA methylation and DNA hydroxymethylation in human brain in PD-related genes, including PARK19 (DNAJC6) and PTPRN2 (IA-2β)

Abstract excerpt

<title>Abstract</title> <p>Background The majority of Parkinson’s disease (PD) cases are due to a complex interaction between aging, genetics, and environmental factors; epigenetic mechanisms are thought to act as important mediators of these risk factors. While multiple studies to date have explored the role of DNA modifications in PD, few focus on 5-hydroxymethylcytosine (5hmC). Because 5hmC occurs at its high...

Topics

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• Autism Spectrum Disorder Research
• Cancer-related gene regulation
• Diet and metabolism studies
• Epigenetics and DNA Methylation
• Genetic Associations and Epidemiology
• Genetic Syndromes and Imprinting
• Neurogenetic and Muscular Disorders Research
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

8f17250f-5691-582e-b27a-70ae248753c4

DOI

10.21203/rs.3.rs-4572401/v1