Article

Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsy

2020-05-11

Abstract excerpt

<h4>Background: </h4> Methylation of mitochondrial tRNAs (mt-tRNA) at the 9 th position (“p9 site”) is known to impact translational efficiency and downstream mitochondrial function; however, direct assessment of mt-RNA methylation is challenging. Recent RNA sequence-based methods have been developed to reliably identify post-transcriptional methylation. Though p9 methylation has been studied in healthy human popu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 406956eb-7de7-56f6-b1c8-ebf0b02ea258
DOI: 10.21203/rs.2.20546/v4

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsyDOI 10.21203/rs.2.20546/v4Read

Differential expression of m5C RNA methyltransferase genes NSUN6 and NSUN7 in Alzheimer’s disease and Traumatic Brain InjurySemantic proximity Read

Dysregulation of RNA modification systems in clinical populations with neurocognitive disordersSemantic proximity Read

Rewired m6A methylation of promoter antisense RNAs in Alzheimer’s disease regulates global gene transcription in the 3D nucleomeSemantic proximity Read

MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsySemantic proximity Read

The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA HypermethylationSemantic proximity Read

ALS and FTD: an epigenetic perspective.Semantic proximity Read

RNA methylation modifications in neurodegenerative diseases: Focus on their enzyme systemSemantic proximity Read

DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: A cross-comparative investigationSemantic proximity Read

Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastomaSemantic proximity Read

Ultra-deep whole genome bisulfite sequencing reveals a single methylation hotspot in human brain mitochondrial DNASemantic proximity Read

Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals <i>OTUD4</i> in shared dysregulated signatures across pathological subtypesSemantic proximity Read

Molecular Disease Stages of Oligodendrocytic and Neuronal Tau Burden in Progressive Supranuclear PalsySemantic proximity Read