Article

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4 <sup>+</sup> T Cell Help

2025-06-30

Abstract excerpt

Red blood cell (RBC) alloimmunization to non-ABO antigens is a major clinical complication for chronically transfused patients. When exposed to transfused RBCs carrying foreign antigens, some patients generate IgG antibodies that target these antigens, creating potential barriers to future transfusions. Interestingly, other patients produce only IgM antibodies against the same non-ABO antigens, which generally hav...

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Literature Corpus work: bad646f1-197c-5eb4-b279-1259f8ff9f9c
DOI: 10.1101/2025.06.26.661795

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