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Article

High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.

The Journal of experimental medicine - 6 Dec 1999

Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch J V, Honjo T, Izui S

Abstract excerpt

To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared its pathogenic potential with that of its IgM isotype and a high-affinity 3...

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Share to Anemia, Hemolytic, Autoimmune
Share to Autoantibodies
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin G

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Share to Immunoglobulin Switch Region

Share to Receptors, Fc

Source

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Identifiers

PMID: 10587359
DOI: 10.1084/jem.190.11.1689
PMCID: PMC2195740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10587359-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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