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Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cells

12 Apr 2012

Abstract excerpt

BACKGROUND: KEL1, also known as "K", is one of the most immunogenic red blood cell (RBC) antigens. KEL2, also known as "k," differs from KEL1 by a single amino acid. Anti-Kell system antibodies can lead to significant adverse clinical outcomes in humans, including hemolytic complications in alloimmunized transfusion recipients or in infants of alloimmunized mothers. To provide a platform for in-depth immunologic...

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PMID: 22494154
DOI: 10.1111/j.1537-2995.2012.03641.x

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