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Article

The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice.

EBioMedicine - 1 Jul 2016

Gibb David R, Calabro Samuele, Liu Dong, Tormey Christopher A, Spitalnik Steven L, Zimring James C, Hendrickson Jeanne E, Hod Eldad A, Eisenbarth Stephanie C

Abstract excerpt

Red blood cell (RBC) transfusions are essential for patients with hematological disorders and bone marrow failure syndromes. Despite ABO matching, RBC transfusions can lead to production of alloantibodies against "minor" blood group antigens. Non-ABO alloimmunization is a leading cause of transfusion-associated mortality in the U.S. Despite its clinical importance, little is known about the immunological factors...

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Share to Blood Group Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NLR Family, Pyrin Domain-Containing 3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 27345021
DOI: 10.1016/j.ebiom.2016.06.008
PMCID: PMC4972549

Genes

NLRP3
ABO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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