Article

Class switching is differentially regulated in RBC alloimmunization and vaccination

2023-01-12

Abstract excerpt

<h4>Background</h4> Studies of human patients have shown that most anti-RBC alloantibodies are IgG1 or IgG3 subclasses, though it is unclear why transfused RBCs preferentially drive these subclasses over others. Though mouse models allow for the mechanistic exploration of class-switching, previous studies of RBC alloimmunization in mice have focused more on the total IgG response than the relative distribution, a...

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Literature Corpus work: b4963727-72fc-5620-8bc1-ca62885d5418
DOI: 10.1101/2023.01.11.523608

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