Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization

Abstract excerpt

Despite the significant clinical consequences of red blood cell (RBC) alloimmunization, our understanding of the fundamental molecular and cellular mechanisms regulating anti-RBC antibody generation is limited. Relative to infectious stimuli,[1][1] transfused RBCs induce a less robust antibody

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