Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complement serves as a switch between CD4+ T cell–independent and –dependent RBC antibody responses

14 Nov 2018

Abstract excerpt

RBC alloimmunization represents a significant immunological challenge for patients requiring lifelong transfusion support. The majority of clinically relevant non-ABO(H) blood group antigens have been thought to drive antibody formation through T cell-dependent immune pathways. Thus, we initially sought to define the role of CD4+ T cells in formation of alloantibodies to KEL, one of the leading causes of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood groups and transfusion
Share to Diabetes and associated disorders
Share to Erythrocyte Function and Pathophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30429364
DOI: 10.1172/jci.insight.121631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complement serves as a switch between CD4+ T cell–independent and –dependent RBC antibody responsesPMID 30429364Read ↗

An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLASemantic proximity Read ↗

Red Blood Cell Transfusion is a Non-Canonical Immune Stimulus Characterized by the Suboptimal Induction of CD4 <sup>+</sup> T Cell HelpSemantic proximity Read ↗

Transfusion of allogenic murine HOD red blood cells preferentially induces low-affinity, short-lived IgG antibodies that are germinal center independentSemantic proximity Read ↗

Red blood cell alloimmunization mitigation strategies.Semantic proximity Read ↗

The Biology of IgG Subclasses and Their Clinical Relevance to TransplantationSemantic proximity Read ↗

Alloantibodies to a paternally derived RBC KEL antigen lead to hemolytic disease of the fetus/newborn in a murine modelSemantic proximity Read ↗

Generation of transgenic mice with antithetical KEL1 and KEL2 human blood group antigens on red blood cellsSemantic proximity Read ↗

Pathobiology of Transfusion ReactionsSemantic proximity Read ↗

The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice.Semantic proximity Read ↗

Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunizationSemantic proximity Read ↗

Spotlight on pathogenesis of TRALI: HNA-3a (CTL2) antibodies.Semantic proximity Read ↗

The continuing saga of complement receptor type 3 (CR3)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.