Article

Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas

2025-09-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profiling in patient-derived organoids of-fers a powerful strategy to further refine patient stratification. While (epi)genetic profiling has drastically improved the classification in diffuse ad...

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Literature Corpus work: babfa69c-6e78-5a2b-8ce4-324de0faad49
DOI: 10.1101/2025.09.09.675145

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