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Article

Patient-derived glioblastoma organoids reflect tumor heterogeneity and treatment sensitivity

1 Jan 2023

Abstract excerpt

Abstract Background Treatment resistance and tumor relapse are the primary causes of mortality in glioblastoma (GBM), with intratumoral heterogeneity playing a significant role. Patient-derived cancer organoids have emerged as a promising model capable of recapitulating tumor heterogeneity. Our objective was to develop patient-derived GBM organoids (PGO) to investigate treatment response and resistance. Methods...

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PMID: 38130902
DOI: 10.1093/noajnl/vdad152

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