Article

Single-cell landscapes of primary glioblastomas and matched organoids and cell lines reveal variable retention of inter- and intra-tumor heterogeneity

2021-04-26

Abstract excerpt

<h4>Summary</h4> Glioblastomas (GBMs) are aggressive primary malignant brain tumors characterized by extensive levels of inter- and intra-tumor genetic and phenotypic heterogeneity. Patient-derived organoids (PDOs) have recently emerged as useful models to study such heterogeneity. Here, we present bulk exome as well as single-cell genome and transcriptome profiles of primary IDH wild type GBMs from ten patients...

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Literature Corpus work: e225605f-2f89-5c55-bb75-34d4c534adcc
DOI: 10.1101/2021.04.24.441206

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