Article

A Multi-Omic Phenobank Reveals Axes of Glioblastoma Growth, Invasion, and Therapeutic Vulnerability

2025-03-28

Abstract excerpt

<h4>Background</h4> Glioblastoma (GBM) invasion is clinically decisive but difficult to model systematically. Existing patient-derived xenograft (PDX) resources rarely couple reproducible in vivo invasion phenotypes with matched multi-omic profiles at scale, limiting mechanistic insight and phenotype-informed therapeutic hypotheses. <h4>Methods</h4> We established the HGCC Phenobank , comprising 65 patient-de...

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Literature Corpus work: 03abf684-2f70-55da-b6ea-b2905fc52d67
DOI: 10.1101/2025.03.25.645260

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