Article

Balancing potency and differentiation in mouse embryo-derived stem cells and in vivo

2012-01-01

Abstract excerpt

An inherent challenge for developing organisms is to maintain a critical balance between cell potency and differentiation. This is most obvious in embryonic stem (ES) cells where genetic, epigenetic and cell signalling pathways support ES cell ability to self-renew and to generate all embryonic lineages. Recently, a series of reports revealed how Polycomb-mediated repression might buffer the precocious expression...

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Literature Corpus work: ba8f065d-52f8-59ef-abde-f76028fd96e8
DOI: 10.25560/9473

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