Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs.

Nature structural & molecular biology - 1 Dec 2005

Hamma Tomoko, Reichow Steve L, Varani Gabriele, Ferré-D'Amaré Adrian R

Abstract excerpt

Box H/ACA ribonucleoprotein particles (RNPs) catalyze RNA pseudouridylation and direct processing of ribosomal RNA, and are essential architectural components of vertebrate telomerases. H/ACA RNPs comprise four proteins and a multihelical RNA. Two proteins, Cbf5 and Nop10, suffice for basal enzymatic activity in an archaeal in vitro system. We now report their cocrystal structure at 1.95-A resolution. We find...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Archaeal Proteins
Share to Conserved Sequence
Share to Crystallography

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methanococcus

Share to Ribonucleoproteins, Small Nucleolar

Share to RNA-Binding Proteins

Share to Telomerase

Source

Identifiers

PMID: 16286935
DOI: 10.1038/nsmb1036

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs.PMID 16286935Read ↗

Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.Semantic proximity Read ↗

Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.Semantic proximity Read ↗

Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPsSemantic proximity Read ↗

Interprotomer communication and functional asymmetry in H/ACA snoRNPs.Semantic proximity Read ↗

How a single protein complex accommodates many different H/ACA RNAs.Semantic proximity Read ↗

Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.Semantic proximity Read ↗

Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.Semantic proximity Read ↗

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled <i>In Vivo</i>Semantic proximity Read ↗

Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea.Semantic proximity Read ↗

The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.Semantic proximity Read ↗

Refined secondary-structure models of the core of yeast and human telomerase RNAs directed by SHAPESemantic proximity Read ↗

The many facets of H/ACA ribonucleoproteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.