Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled <i>In Vivo</i>

29 Mar 2010

Abstract excerpt

The H/ACA motif of human telomerase RNA (hTR) directs specific pathways of endogenous telomerase holoenzyme assembly, function, and regulation. Similarities between hTR and other H/ACA RNAs have been established, but differences have not been explored even though unique features of hTR H/ACA RNP assembly give rise to telomerase deficiency in human disease. Here, we define hTR H/ACA RNA and RNP architecture using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bioluminescence and chemiluminescence research
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20351177
DOI: 10.1128/mcb.00151-10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specificity and Stoichiometry of Subunit Interactions in the Human Telomerase Holoenzyme Assembled <i>In Vivo</i>PMID 20351177Read ↗

Distinct biogenesis pathways for human telomerase RNA and H/ACA small nucleolar RNAs.Semantic proximity Read ↗

Dyskeratosis congenita mutations in the H/ACA domain of human telomerase RNA affect its assembly into a pre-RNP.Semantic proximity Read ↗

Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.Semantic proximity Read ↗

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodiesSemantic proximity Read ↗

Structure of human telomerase holoenzyme with bound telomeric DNA.Semantic proximity Read ↗

Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants.Semantic proximity Read ↗

Telomerase RNA processing: Implications for human health and diseaseSemantic proximity Read ↗

Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs.Semantic proximity Read ↗

How a single protein complex accommodates many different H/ACA RNAs.Semantic proximity Read ↗

Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10pSemantic proximity Read ↗

Structure–function relationship and biogenesis regulation of the human telomerase holoenzymeSemantic proximity Read ↗

A Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ EndSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.