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Article

Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.

Genes & development - 15 Nov 2011

Li Shuang, Duan Jingqi, Li Dandan, Yang Bing, Dong Mengqiu, Ye Keqiong

Abstract excerpt

Box H/ACA ribonucleoprotein particles (RNPs) mediate pseudouridine synthesis, ribosome formation, and telomere maintenance. The structure of eukaryotic H/ACA RNPs remains poorly understood. We reconstituted functional Saccharomyces cerevisiae H/ACA RNPs with recombinant proteins Cbf5, Nop10, Gar1, and Nhp2 and a two-hairpin H/ACA RNA; determined the crystal structure of a Cbf5, Nop10, and Gar1 ternary complex at...

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Identifiers

PMID: 22085967
DOI: 10.1101/gad.175299.111
PMCID: PMC3222906

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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