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Article

Human dyskerin: beyond telomeres

27 Jan 2014

Abstract excerpt

Human dyskerin is an evolutively conserved protein that participates in diverse nuclear complexes: the H/ACA snoRNPs, that control ribosome biogenesis, RNA pseudouridylation, and stability of H/ACA snoRNAs; the scaRNPs, that control pseudouridylation of snRNAs; and the telomerase active holoenzyme, which safeguards telomere integrity. The biological importance of dyskerin is further outlined by the fact that its...

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PMID: 24468621
DOI: 10.1515/hsz-2013-0287

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Related research

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Human dyskerin: beyond telomeresPMID 24468621Read ↗

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.Semantic proximity Read ↗

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Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer.Semantic proximity Read ↗

Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs.Semantic proximity Read ↗

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