Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.

Genes & development - 15 Nov 2011

Walbott Hélène, Machado-Pinilla Rosario, Liger Dominique, Blaud Magali, Réty Stéphane, Grozdanov Petar N, Godin Kate, van Tilbeurgh Herman, Varani Gabriele, Meier U Thomas, Leulliot Nicolas

Abstract excerpt

SHQ1 is an essential assembly factor for H/ACA ribonucleoproteins (RNPs) required for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance. SHQ1 binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, and this interaction is modulated by mutations causing X-linked dyskeratosis congenita. We report the crystal structure of the C-terminal domain of yeast SHQ1, Shq1p, and its complex with yeast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Survival
Share to Hydro-Lyases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microtubule-Associated Proteins

Share to Molecular Mimicry

Share to Protein Folding

Share to Ribonucleoproteins, Small Nuclear

Share to Ribonucleoproteins, Small Nucleolar

Share to RNA, Fungal

Source

Open in PubMed Open full text

Identifiers

PMID: 22085966
DOI: 10.1101/gad.176834.111
PMCID: PMC3222905

Genes

SHQ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic.PMID 22085966Read ↗

Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita.Semantic proximity Read ↗

Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1.Semantic proximity Read ↗

Pathogenic NAP57 mutations decrease ribonucleoprotein assembly in dyskeratosis congenita.Semantic proximity Read ↗

How a single protein complex accommodates many different H/ACA RNAs.Semantic proximity Read ↗

Interprotomer Communication and Functional Asymmetry in H/ACA snoRNPsSemantic proximity Read ↗

Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins.Semantic proximity Read ↗

Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase.Semantic proximity Read ↗

Interprotomer communication and functional asymmetry in H/ACA snoRNPs.Semantic proximity Read ↗

hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomeraseSemantic proximity Read ↗

Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance.Semantic proximity Read ↗

Effects of dyskeratosis congenita mutations in dyskerin, NHP2 and NOP10 on assembly of H/ACA pre-RNPs.Semantic proximity Read ↗

Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.