Article
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita.
Molecular cell - 20 Jan 2006
Rashid Rumana, Liang Bo, Baker Daniel L, Youssef Osama A, He Yang, Phipps Kathleen, Terns Rebecca M, Terns Michael P, Li Hong
Abstract excerpt
H/ACA RNA-protein complexes, comprised of four proteins and an H/ACA guide RNA, modify ribosomal and small nuclear RNAs. The H/ACA proteins are also essential components of telomerase in mammals. Cbf5 is the H/ACA protein that catalyzes isomerization of uridine to pseudouridine in target RNAs. Mutations in human Cbf5 (dyskerin) lead to dyskeratosis congenita. Here, we describe the 2.1 A crystal structure of a...
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