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Article

Interprotomer communication and functional asymmetry in H/ACA snoRNPs.

Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2025

Panwar Hemendra Singh, Vos Timothy J, Xie Xiaoyan, Jang H Josh, Lee Hyoungjoo, Sheldon Ryan D, Worden Evan J, Kothe Ute

Abstract excerpt

H/ACA small nucleolar ribonucleoproteins (H/ACA snoRNPs) facilitate essential cellular processes such as RNA modification, folding, and stability. Here, we present multiple cryo-EM structures of endogenous insect H/ACA snoRNPs containing two protomers assembled on a two-hairpin H/ACA snoRNA. By characterizing key protein-protein and protein-RNA interactions, we reveal the coordination of pseudouridylation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41410763
DOI: 10.1073/pnas.2514683122
PMCID: PMC12745780

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