Article

NanoSimFormer: An end-to-end Transformer-based simulator for nanopore sequencing signal data

2026-01-25

Abstract excerpt

Nanopore sequencing has achieved a new standard of accuracy with the advent of R10.4.1 flow cell and high-performance Transformer-based basecalling models. However, existing signal simulators often fail to capture the complex, non-linear dynamics of nanopore current signals, relying on static pore models or lacking optimization objectives linked to basecalling, resulting in synthetic signals with substantially low...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba3e60e4-dfa7-516c-8aa3-0525187301f3
DOI: 10.64898/2026.01.20.700442

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NanoSimFormer: An end-to-end Transformer-based simulator for nanopore sequencing signal dataDOI 10.64898/2026.01.20.700442Read

NanoSimFormer: an end-to-end transformer-based nanopore signal simulator with basecaller guidance.Semantic proximity Read

Targeted nanopore sequencing by real-time mapping of raw electrical signal with UNCALLED.Semantic proximity Read

De novo sequencing and variant calling with nanopores using PoreSeq.Semantic proximity Read

Targeted nanopore sequencing by real-time mapping of raw electrical signal with UNCALLEDSemantic proximity Read

RNA folding below the nanopore impairs direct RNA sequencing fidelity and modification callingSemantic proximity Read

A whole-genome sequencing dataset of nanopore raw signals for bacterial genotyping and methylation analysis.Semantic proximity Read

SquiDBase: a community resource of raw nanopore data from microbesSemantic proximity Read

ConSeqUMI, an error-free nanopore sequencing pipeline to identify and extract individual nucleic acid molecules from heterogeneous samplesSemantic proximity Read

Coral: a dual context-aware basecaller for nanopore direct RNA sequencingSemantic proximity Read

Leveraging ONT move table values for signal aware variant calling.Semantic proximity Read

Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignmentSemantic proximity Read

NanoReviser: An Error-correction Tool for Nanopore Sequencing Based on a Deep Learning AlgorithmSemantic proximity Read