Article

Uncalled4 improves nanopore DNA and RNA modification detection via fast and accurate signal alignment

2024-03-11

Abstract excerpt

Nanopore signal analysis enables detection of nucleotide modifications from native DNA and RNA sequencing, providing both accurate genetic/transcriptomic and epigenetic information without additional library preparation. Presently, only a limited set of modifications can be directly basecalled (e.g. 5-methylcytosine), while most others require exploratory methods that often begin with alignment of nanopore signal...

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Literature Corpus work: 0477dee5-a5bb-57d9-a473-192dc13dc9df
DOI: 10.1101/2024.03.05.583511

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