Article
Targeted nanopore sequencing by real-time mapping of raw electrical signal with UNCALLED.
Nature biotechnology - 1 Apr 2021
Kovaka Sam, Fan Yunfan, Ni Bohan, Timp Winston, Schatz Michael C
Abstract excerpt
Conventional targeted sequencing methods eliminate many of the benefits of nanopore sequencing, such as the ability to accurately detect structural variants or epigenetic modifications. The ReadUntil method allows nanopore devices to selectively eject reads from pores in real time, which could enable purely computational targeted sequencing. However, this requires rapid identification of on-target reads while...
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