Article
De novo sequencing and variant calling with nanopores using PoreSeq.
Nature biotechnology - 1 Oct 2015
Szalay Tamas, Golovchenko Jene A
Abstract excerpt
The accuracy of sequencing single DNA molecules with nanopores is continually improving, but de novo genome sequencing and assembly using only nanopore data remain challenging. Here we describe PoreSeq, an algorithm that identifies and corrects errors in nanopore sequencing data and improves the accuracy of de novo genome assembly with increasing coverage depth. The approach relies on modeling the possible...
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