Article

Coral: a dual context-aware basecaller for nanopore direct RNA sequencing

2024-11-21

Abstract excerpt

<title>Abstract</title> <p>Nanopore direct RNA sequencing (DRS) offers distinct advantages for transcriptome analysis over the traditional high-throughput RNA sequencing methods by preserving native RNA modifications, eliminating polymerase chain reaction bias, and simplifying the workflow. However, the high sequencing error rate of nanopore DRS remains a significant hurdle. Here we introduce Coral, a dual contex...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2e7486c9-b5a6-50e1-a7e2-3d06e75c9e28
DOI: 10.21203/rs.3.rs-5396864/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coral: a dual context-aware basecaller for nanopore direct RNA sequencingDOI 10.21203/rs.3.rs-5396864/v1Read

A dual context-aware basecaller for nanopore direct RNA sequencing.Semantic proximity Read

DEMINERS enables clinical metagenomics and comparative transcriptomic analysis by increasing throughput and accuracy of nanopore direct RNA sequencingSemantic proximity Read

NanoSimFormer: an end-to-end transformer-based nanopore signal simulator with basecaller guidance.Semantic proximity Read

RNA BaseCode: Long-Read RNA Sequences with Short-Read AccuracySemantic proximity Read

NanoSimFormer: An end-to-end Transformer-based simulator for nanopore sequencing signal dataSemantic proximity Read

Nm-Nano: A Machine Learning Framework for Transcriptome-Wide Single Molecule Mapping of 2´-O-Methylation (Nm) Sites in Nanopore Direct RNA Sequencing DatasetsSemantic proximity Read

Learning transcriptome architecture from sequence with a long-context RNA foundation modelSemantic proximity Read

RNA folding below the nanopore impairs direct RNA sequencing fidelity and modification callingSemantic proximity Read

ModiDeC: a multi-RNA modification classifier for direct nanopore sequencingSemantic proximity Read

Beyond Annotation: Leveraging Raw RNA-seq Reads via Foundation Models for Multi-Cancer Early DetectionSemantic proximity Read

Single-Molecule Direct RNA Sequencing Reveals the Shaping of Epitranscriptome Across Multiple SpeciesSemantic proximity Read

Adapting Nanopore Sequencing Basecalling Models for Modification Detection via Incremental Learning and Anomaly DetectionSemantic proximity Read