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Article

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.

Neurobiology of disease - 1 Dec 2018

Novello Salvatore, Arcuri Ludovico, Dovero Sandra, Dutheil Nathalie, Shimshek Derya R, Bezard Erwan, Morari Michele

Abstract excerpt

Fibrillization of α-synuclein is instrumental for the development of Parkinson's disease (PD), thus modulating this process can have profound impact on disease initiation/progression. Here, the impact of the p.G2019S mutation of leucine-rich repeat kinase 2 (LRRK2), which is most frequently associated with familial and sporadic PD, on α-synuclein pathology was investigated. G2019S knock-in mice and wild-type...

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Identifiers

PMID: 30172844
DOI: 10.1016/j.nbd.2018.08.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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