G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.

doi:10.1016/j.nbd.2018.08.018

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Article

G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice.

Neurobiology of disease - 1 Dec 2018

Novello Salvatore, Arcuri Ludovico, Dovero Sandra, Dutheil Nathalie, Shimshek Derya R, Bezard Erwan, Morari Michele

Abstract excerpt

Fibrillization of α-synuclein is instrumental for the development of Parkinson's disease (PD), thus modulating this process can have profound impact on disease initiation/progression. Here, the impact of the p.G2019S mutation of leucine-rich repeat kinase 2 (LRRK2), which is most frequently associated with familial and sporadic PD, on α-synuclein pathology was investigated. G2019S knock-in mice and wild-type...

Topics

Aging
Animals
Corpus Striatum
Gene Knock-In Techniques
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Substantia Nigra
alpha-Synuclein

Source

Open in PubMed

Identifiers

PMID: 30172844
DOI: 10.1016/j.nbd.2018.08.018

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