Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse model

9 Jan 2013

Abstract excerpt

BACKGROUND: Progressive accumulation of α-synuclein (α-Syn) protein in different brain regions is a hallmark of synucleinopathic diseases, such as Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. α-Syn transgenic mouse models have been developed to investigate the effects of α-Syn accumulation on behavioral deficits and neuropathology. However, the onset and progression of pathology in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurological disorders and treatments
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23302418
DOI: 10.1186/1471-2202-14-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Time course and progression of wild type α-Synuclein accumulation in a transgenic mouse modelPMID 23302418Read ↗

Early start of progressive motor deficits in Line 61 α-synuclein transgenic miceSemantic proximity Read ↗

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.Semantic proximity Read ↗

Differential neuropathological alterations in transgenic mice expressing α‐synuclein from the platelet‐derived growth factor and Thy‐1 promotersSemantic proximity Read ↗

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease.Semantic proximity Read ↗

α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal ModelsSemantic proximity Read ↗

Human Wild-Type α-Synuclein Drives Progressive Tau Pathology in a Disease-Relevant Mouse Model of SynucleinopathySemantic proximity Read ↗

Modeling Parkinson’s Disease With the Alpha-Synuclein ProteinSemantic proximity Read ↗

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse proteinSemantic proximity Read ↗

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s diseaseSemantic proximity Read ↗

Modeling Parkinson's disease‐related symptoms in alpha‐synuclein overexpressing miceSemantic proximity Read ↗

Accelerated and Localized Synucleinopathy in a Hybrid Mouse Model: Implications for Positron Emission Tomography StudiesSemantic proximity Read ↗

Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.