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Article

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

23 Jun 2017

Abstract excerpt

Abnormal accumulation of alpha-synuclein (αsyn) is a pathological hallmark of Lewy body related disorders such as Parkinson's disease and Dementia with Lewy body disease. During the past two decades, a myriad of animal models have been developed to mimic pathological features of synucleinopathies by over-expressing human αsyn. Although different strategies have been used, most models have little or no reliable...

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PMID: 28645308
DOI: 10.1186/s40478-017-0455-3

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