Article

Cell type-specific contributions to impaired blood-brain barrier and cerebral metabolism in presymptomatic 5XFAD mice

2025-04-26

Abstract excerpt

<h4>Summary</h4> Altered cerebral metabolism and blood-brain barrier (BBB) dysfunction are emerging as critical contributors to the preclinical phase of Alzheimer’s disease (AD), underscoring their role in early pathogenesis. To identify sensitive biomarkers before irreversible neuronal loss and cognitive decline, we examined 5XFAD mice at 3 months of age by applying multiple advanced MRI techniques. Arterial spi...

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Literature Corpus work: a11b30e3-7ece-5d81-bb6a-2664a7136298
DOI: 10.1101/2025.04.23.650260

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