Article

Early reduction of cerebral lactate in Alzheimer’s disease mouse model: The relationship with Aβ production

2022-07-05

Abstract excerpt

Lactate arouses an increasing concern in recent studies of Alzheimer’s disease (AD). At late stage of AD, amyloid beta (Aβ) directly promotes lactate level, continuously activating microglial inflammation and aggravating neuronal damage. However, whether lactate fluctuation can effect on Aβ hasn’t been recognized. Especially, it is observed a reduction of lactate in the hippocampus and cortex of early AD mouse mod...

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Literature Corpus work: e580a523-5496-5280-b927-907b694b2fd7
DOI: 10.21203/rs.3.rs-1780387/v1

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