Article

Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma

2026-06-05

Abstract excerpt

Loss of the Y chromosome (LOY) is associated with poor survival across multiple solid tumors, yet the underlying molecular mechanisms remain poorly understood. Here, we identify LOY as a central driver of lineage plasticity and epigenetic heterogeneity in lung adenocarcinoma. Integrating multi-omic profiling of primary samples with isogenic cellular models, we show that LOY triggers epithelial-to-mesenchymal trans...

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Literature Corpus work: 8ce72d52-f52d-5dfc-86ac-e5b6e9a46441
DOI: 10.64898/2026.06.02.729627

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