Article

A genomically validated loss of chromosome Y transcriptional program is a modest prognostic signal independent of tumour stage in male lung adenocarcinoma

2026-08-07

Abstract excerpt

<title>Abstract</title> <p> Background. Somatic loss of chromosome Y (LOY) is the most common acquired mutation in the male genome and an emerging determinant of cancer aggressiveness and immune evasion, yet whether an LOY-associated transcriptional program constitutes a prognostic axis <italic>independent of tumour stage and generic proliferation</italic> in non-small-cell lung cancer has not been establishe...

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Literature Corpus work: ffd525cc-880b-5f93-bb3b-1b1e7a7b667b
DOI: 10.21203/rs.3.rs-10310328/v1

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