Article

Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patients

2024-11-25

Abstract excerpt

In rare individuals with a severely immunocompromised system, chronic infections of SARS-CoV-2 may develop, where the virus replicates in the body for months. Sequencing of some chronic infections has uncovered dramatic adaptive evolution and fixation of mutations reminiscent of lineage-defining mutations of variants of concern (VOCs). This has led to the prevailing hypothesis that VOCs emerged from chronic infect...

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Literature Corpus work: ba0973c8-d3e4-5db5-b916-f5c32961db12
DOI: 10.1101/2024.11.23.624482

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