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Article

Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts.

PLoS pathogens - 1 Apr 2021

Valesano Andrew L, Rumfelt Kalee E, Dimcheff Derek E, Blair Christopher N, Fitzsimmons William J, Petrie Joshua G, Martin Emily T, Lauring Adam S

Abstract excerpt

Analysis of SARS-CoV-2 genetic diversity within infected hosts can provide insight into the generation and spread of new viral variants and may enable high resolution inference of transmission chains. However, little is known about temporal aspects of SARS-CoV-2 intrahost diversity and the extent to which shared diversity reflects convergent evolution as opposed to transmission linkage. Here we use high depth of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33826681
DOI: 10.1371/journal.ppat.1009499
PMCID: PMC8055005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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