Article

Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infections

2025-02-14

Abstract excerpt

Persistent SARS-CoV-2 infections have been hypothesized to play a key role in the emergence of variants of concern. However, the factors determining which individuals are at risk and their viral molecular signatures during infection remain poorly understood. Using the extensive COVID-19 surveillance database in Denmark, comprising over 700,000 genomes, we identified 303 persistent infections and, critically, linke...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0cdcbb77-3342-5a34-9071-b225a7ccd3c5
DOI: 10.1101/2025.02.10.25321987

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infectionsDOI 10.1101/2025.02.10.25321987Read

Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infections.Semantic proximity Read

Immunosuppression as a hub for SARS-CoV-2 mutational driftSemantic proximity Read

Combined Effects of Severe Immunocompromise and Prolonged Virus Shedding on Within-Host SARS-CoV-2 Evolution in COVID-19Semantic proximity Read

SARS-CoV-2 genomic diversity and within-host evolution in individuals with persistent infection in the UK: an observational, longitudinal, population-based surveillance study.Semantic proximity Read

Intra-host viral populations of SARS-CoV-2 in immunosuppressed patients with hematologic cancersSemantic proximity Read

SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.Semantic proximity Read

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.Semantic proximity Read

Emergence of multiple SARS-CoV-2 mutations in an immunocompromised hostSemantic proximity Read

High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance studySemantic proximity Read

SARS-CoV-2 shedding and evolution in immunocompromised hosts during the Omicron period: a multicenter prospective analysisSemantic proximity Read

Intra-host evolution during SARS-CoV-2 persistent infectionSemantic proximity Read

Diverse patterns of intra-host genetic diversity in chronically infected SARS-CoV-2 patientsSemantic proximity Read