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SARS-CoV-2 population dynamics in immunocompetent individuals in a closed transmission chain shows genomic diversity over the course of infection.

Genome medicine - 16 Jul 2024

Goldswain Hannah, Penrice-Randal Rebekah, Donovan-Banfield I'ah, Duffy Craig W, Dong Xiaofeng, Randle Nadine, Ryan Yan, Rzeszutek Aleksandra M, Pilgrim Jack, Keyser Emma, Weller Simon A, Hutley Emma J, Hartley Catherine, Prince Tessa, Darby Alistair C, Aye Maung Niall, Nwume Henry, Hiscox Julian A, Emmett Stevan R

Abstract excerpt

BACKGROUND: SARS-CoV-2 remains rapidly evolving, and many biologically important genomic substitutions/indels have characterised novel SARS-CoV-2 lineages, which have emerged during successive global waves of the pandemic. Worldwide genomic sequencing has been able to monitor these waves, track transmission clusters, and examine viral evolution in real time to help inform healthcare policy. One school of thought...

Topics

Humans
SARS-CoV-2
COVID-19
Genome, Viral
Male
Adult
Female
Middle Aged
Genetic Variation
Immunocompetence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Evolution, Molecular

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Identifiers

PMID: 39014481
DOI: 10.1186/s13073-024-01360-1
PMCID: PMC11251137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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