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Article

Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks.

PLoS pathogens - 1 Aug 2021

Braun Katarina M, Moreno Gage K, Wagner Cassia, Accola Molly A, Rehrauer William M, Baker David A, Koelle Katia, O'Connor David H, Bedford Trevor, Friedrich Thomas C, Moncla Louise H

Abstract excerpt

The emergence of divergent SARS-CoV-2 lineages has raised concern that novel variants eliciting immune escape or the ability to displace circulating lineages could emerge within individual hosts. Though growing evidence suggests that novel variants arise during prolonged infections, most infections are acute. Understanding how efficiently variants emerge and transmit among acutely-infected hosts is therefore...

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Identifiers

PMID: 34424945
DOI: 10.1371/journal.ppat.1009849
PMCID: PMC8412271

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