Article

Drivers of adaptive evolution during chronic SARS-CoV-2 infections

2022-02-28

Abstract excerpt

In some immunocompromised patients with chronic SARS-CoV-2 infection, dramatic adaptive evolution occurs, with substitutions reminiscent of those in variants of concern (VOCs). Here, we searched for drivers of VOC-like emergence by consolidating sequencing results from a set of twenty-seven chronic infections. Most substitutions in this set reflected lineage-defining VOC mutations, yet a subset of mutations associ...

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Literature Corpus work: ed03b9bc-8aad-5455-904d-9b44c066c774
DOI: 10.1101/2022.02.17.22270829

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