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Article

Large-scale genomic surveillance reveals immunosuppression drives mutation dynamics in persistent SARS-CoV-2 infections.

Nature communications - 19 Jun 2026

Khurana Mark P, Katsiferis Alexandros, Scheidwasser Neil, Sloth Mathilde Marie Brünnich, Curran-Sebastian Jacob, Morgenstern Christian, Tang Man-Hung Eric, Fonager Jannik, Rasmussen Morten, Stegger Marc, Lehmann Sune, Whittaker Charles, Mortensen Laust H, Jokelainen Pikka, Kraemer Moritz U G, Ferguson Neil M, Ghafari Mahan, Krause Tyra G, Duchêne David A, Bhatt Samir

Abstract excerpt

Persistent SARS-CoV-2 infections have been hypothesized to play a key role in the emergence of variants of concern. However, the factors determining which individuals are at risk and their viral molecular signatures during infection remain poorly understood. Using Denmark's extensive COVID-19 surveillance, comprising over 700,000 genomes, we identify 303 persistent infections and, critically, link them to health...

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Identifiers

PMID: 42321162
DOI: 10.1038/s41467-026-74445-7
PMCID: PMC13433919

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