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Article

Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection.

Cell reports. Medicine - 21 Feb 2023

Chaguza Chrispin, Hahn Anne M, Petrone Mary E, Zhou Shuntai, Ferguson David, Breban Mallery I, Pham Kien, Peña-Hernández Mario A, Castaldi Christopher, Hill Verity, Schulz Wade, Swanstrom Ronald I, Roberts Scott C, Grubaugh Nathan D

Abstract excerpt

The chronic infection hypothesis for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant emergence is increasingly gaining credence following the appearance of Omicron. Here, we investigate intrahost evolution and genetic diversity of lineage B.1.517 during a SARS-CoV-2 chronic infection lasting for 471 days (and still ongoing) with consistently recovered infectious virus and high viral...

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Identifiers

PMID: 36791724
DOI: 10.1016/j.xcrm.2023.100943
PMCID: PMC9906997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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