Patterns of within-host genetic diversity in SARS-CoV-2.

doi:10.7554/eLife.66857

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Article

Patterns of within-host genetic diversity in SARS-CoV-2.

eLife - 13 Aug 2021

Tonkin-Hill Gerry, Martincorena Inigo, Amato Roberto, Lawson Andrew R J, Gerstung Moritz, Johnston Ian, Jackson David K, Park Naomi, Lensing Stefanie V, Quail Michael A, Gonçalves Sónia, Ariani Cristina, Spencer Chapman Michael, Hamilton William L, Meredith Luke W, Hall Grant, Jahun Aminu S, Chaudhry Yasmin, Hosmillo Myra, Pinckert Malte L, Georgana Iliana, Yakovleva Anna, Caller Laura G, Caddy Sarah L, Feltwell Theresa, Khokhar Fahad A, Houldcroft Charlotte J, Curran Martin D, Parmar Surendra, Alderton Alex, Nelson Rachel, Harrison Ewan M, Sillitoe John, Bentley Stephen D, Barrett Jeffrey C, Torok M Estee, Goodfellow Ian G, Langford Cordelia, Kwiatkowski Dominic

Abstract excerpt

Monitoring the spread of SARS-CoV-2 and reconstructing transmission chains has become a major public health focus for many governments around the world. The modest mutation rate and rapid transmission of SARS-CoV-2 prevents the reconstruction of transmission chains from consensus genome sequences, but within-host genetic diversity could theoretically help identify close contacts. Here we describe the patterns of...

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PMID: 34387545
DOI: 10.7554/eLife.66857
PMCID: PMC8363274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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