Article

Spaceflight-relevant microgravity triggers a sublethal Parkinson’s-like dopaminergic decline in human neurons and organoids

2026-07-15

Abstract excerpt

Spaceflight stressors may increase Parkinson’s disease (PD) risk, but microgravity’s specific contribution to human dopaminergic (DA) vulnerability remains undefined. Here, we exposed human iPSC-derived midbrain DA organoids and differentiated SH-SY5Y neurons to simulated microgravity for 72 hours. This exposure reduced neurite outgrowth, eroded DA identity, and activated familial-PD mitochondrial kinases without...

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Literature Corpus work: ba07b6cc-9d7d-52d9-bf63-5fb5ffedb436
DOI: 10.64898/2026.07.09.737494

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