Article

Nicotinamide Riboside Supplementation Ameliorates Mitochondrial Dysfunction and Neuronal Loss in POLG Mutant Midbrain Organoids

2023-11-11

Abstract excerpt

Mitochondrial dysfunction is associated with many neurodegenerative disorders and is particularly prominent in conditions tied to POLG mutations. POLG encodes DNA polymerase gamma vital for mitochondrial DNA replication. Employing 3D human pluripotent stem cell-derived midbrain organoids (hMOs), harbouring POLG mutations, this study explores their differentiation, transcriptional alterations, and underlying pat...

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Literature Corpus work: 0e0d13f0-f01c-528e-93a7-92bddb815985
DOI: 10.1101/2023.11.08.566203

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