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Simulated microgravity accelerates alpha-synuclein aggregation and induces oxidative stress in an <i>in vitro</i> Parkinson’s disease model

2024-10-25

Abstract excerpt

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the accumulation of alpha-synuclein aggregates and progressive neuronal loss in the substantia nigra, with aging being its primary risk factor. The current available models to study PD mechanisms are largely relying on genetic mutations to recapitulate PD typical hallmarks, such as increased alpha-synuclein aggregation. However, they do not...

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Literature Corpus work
af7e1ffa-00d5-5569-9b3b-e069c24be361
DOI
10.1101/2024.10.25.620204
Open publication

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Simulated microgravity accelerates alpha-synuclein aggregation and induces oxidative stress in an <i>in vitro</i> Parkinson’s disease modelDOI 10.1101/2024.10.25.620204
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