Article

Dormant viral pathways underlie space-induced neural senescence

2025-11-04

Abstract excerpt

<h4>SUMMARY</h4> Long-duration spaceflight is associated with neurological symptoms in astronauts, yet the underlying molecular mechanisms remain unclear. Using human brain organoids cultured aboard the International Space Station, we analyzed three independent spaceflights to demonstrate that exposure to the space environment triggers Space-Induced Neural Senescence (SINS), characterized by chromatin remodeling,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ba4e028-510e-589f-8f5a-75f816b97d0c
DOI: 10.1101/2025.11.02.686043

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dormant viral pathways underlie space-induced neural senescenceDOI 10.1101/2025.11.02.686043Read

Microgravity Remodels Longevity Networks in Astronaut PBMCs: Integrated Findings of Telomere Elongation, DNA Repair Responses, and miRNA SuppressionSemantic proximity Read

Resurrection of endogenous retroviruses during aging reinforces senescenceSemantic proximity Read

Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal agingSemantic proximity Read

Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative DiseasesSemantic proximity Read

Telomeres and aging: on and off the planet!Semantic proximity Read

Spatially resolved multiomics on the neuronal effects induced by spaceflightSemantic proximity Read

Spaceflight-relevant microgravity triggers a sublethal Parkinson’s-like dopaminergic decline in human neurons and organoidsSemantic proximity Read

Accelerated Hematopoietic Stem Cell Aging in SpaceSemantic proximity Read

Warning SINEs: <i>Alu</i> elements, evolution of the human brain, and the spectrum of neurological diseaseSemantic proximity Read

Macrophage Migration Inhibitory Factor (MIF) Overexpression Induced by SARS-CoV-2 Infection Promotes Neural Regeneration in Human Brain OrganoidsSemantic proximity Read

Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element ActivationSemantic proximity Read

Telomere Length Dynamics and DNA Damage Responses Associated with Long-Duration SpaceflightSemantic proximity Read