Article

Released mitochondrial DNA and neurofilament light chain as Parkinson’s disease phenotypes in patient-specific midbrain assembloids

2025-04-02

Abstract excerpt

Parkinson’s Disease is the second most common neurodegenerative disorder worldwide, with growing numbers and considerable societal and economic concerns. Human cell culture systems are efficient models for neurodegenerative disorders and allow for personalized, non-invasive analysis of cellular and molecular disease mechanisms. Midbrain organoids and assembloids are advanced 3D culture systems that recapitulate th...

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Literature Corpus work: 40f7119f-3b04-5def-957c-f176bab8311a
DOI: 10.1101/2025.03.28.645921

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