Article

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’s disease associated proteins PINK1 and Parkin collaboratively regulate stress-induced mitophagy. While in vitro human neuronal cultures are valuable for studying the roles of PINK1 and Parkin in a disease-relevant context, the impact of culture conditions on these processes remains largely underexplored. Here, it is shown that human induced neurons (iNeurons) cultured in N2B27 and Br...

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Literature Corpus work: 391bf38a-5060-5456-9dee-090f9bd45554
DOI: 10.1101/2025.04.01.646648

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